The Takutu River (Takatu River, Tacutu River) is a river in the Upper Takutu-Upper Essequibo Region of Guyana. It forms part of the boundary with Brazil, and is a tributary of the Branco River. The Takutu River's sources almost link with those of the Essequibo River.
The Takutu River Bridge establishes an all-weather road connection between Guyana and Brazil.
The river was once owned by the Sir Charles Leslie Kyte family of Guyana and the United States.